Effect of nitrofurans antagonistic to 3'-methyl-4-dimethylaminoazobenzene in hepatocarcinogenesis and RNA polymerase activity of liver cell nuclei in rats.
نویسندگان
چکیده
RNA polymerase activity of liver nuclei; and (c) whether the nitrofurans ameliorated 3'-Me-DAB-induced changes in RNA polymerase activity. The nitrofurans were 2-(2furyl)-3-(5-nitro-2-furyl)acrylamide and 2-amino-5-[2-(5nitro-2-furyl)-l-(2-furyl)vinyl-l-]-l ,3,4-oxadiazole. Male Donryu rats were fed 1 or 0.5 g of 3'-Me-DAB by being maintained on a diet containing 0.06% 3'-Me-DAB or 3'-Me-DAB plus 0.2% of a nitrofuran, and then they were
منابع مشابه
Studies on chromatin. II. Effects of carcinogens and hormones on rat liver chromatin.
Nuclei were isolated from rat liver during the prolonged feeding of the 2 carcinogens, N-hydroxy^-acetylaminofluorene and 3'-methyl-4-dimethylaminoazobenzene, and during the pro longed feeding of the noncarcinogen, 2-methyl-4-dimethylaminoazobenzene. Nuclei were also isolated from rat liver tumors induced by the above carcinogens. Chromatin was isolated from these nuclei and analyzed for RNA, t...
متن کاملIrreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis.
azobenzene for 60 days. The muscle type aldolase in the livers of rats thus treated was found to be elevated when compared to nor mal liver, although no appreciable differences were ob served in total aldolase activity, mitotic index, histological architecture, and soluble protein, as well as DNA content. The appearance of this enzymic change was already observable by administrating the azo dye...
متن کاملAnalysis of loss of nuclear RNA in azo dye-induced hepatoma by DNA-RNA competitive hybridization.
DNA-RNA hybridization studies, using nuclear RNA's (nRNA's) labeled in vivo and in vitro with high specific radioactivities, were performed to compare the nRNA populations of normal rat liver, livers treated with 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB), and 3'-Me-DAB-induced hepatomas. The study with normal liver nRNA labeled by i.p. injection of [3H]orotic acid indicated that the nucle...
متن کاملExpression of albumin messenger RNA detected by in situ hybridization in preneoplastic and neoplastic lesions in rat liver.
The process of chemical hepatocarcinogenesis is characterized by the appearance of preneoplastic lesions showing changes in the expression of various marker enzymes. We have analyzed the phenotype of small preneoplastic foci and expansively growing nodules in liver sections obtained from rats treated with various carcinogens. Changes within the lesions in canalicular adenosine triphosphatase, g...
متن کاملThe effect of feeding 3'-methyl-4-dimethylaminoazobenzene on tryptophan metabolism of rats.
Liver tryptophan pyrrolase and kynureninase activity decreased when rats were fed the hepatic carcinogen 3'-methyl-4-dimethylaminoazobenzene, whereas li ver kynurenine transaminase activity did not differ significantly from that of the controls. Liver tumors induced by this aminoazo dye had very low kynurenine transaminase activity and no detectable tryptophan pyrrolase or kynureninase activity...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 34 8 شماره
صفحات -
تاریخ انتشار 1974